There are various advantages and disadvantages of purchasing real estate in St. Louis, Missouri:

Advantages:
- Affordability: St. Louis has a relatively low cost of living compared to other major cities in the US, including a low median home price compared to national averages.
- Strong job market: The economy in St. Louis is diverse, with a variety of strong industries that include healthcare, biomedical research, and defense. Additionally, the city is home to multiple Fortune 500 companies such as Express Scripts, Edward Jones, and Emerson Electric.
- High rental yield: St. Louis has a high demand for rental properties, making it a great place for real estate investors who are looking for cash flow. Landlords can benefit from high rental yields that can generate significant income.
- Low taxes: Missouri is a tax-friendly state, with no sales tax on groceries and special tax incentives for homeowners.

Disadvantages:
- Slow appreciation: St. Louis has a relatively slow appreciation rate compared to other major cities in the US, meaning there may be fewer opportunities for capital gains in the short term.
- High crime rate: St. Louis has a high crime rate, including a high number of violent crimes. This can be a deterrent for some prospective home buyers and investors.
- Limited job growth: Although the job market is strong, job growth in the area may be limited in the long term. This could make it more difficult for homeowners and landlords to find stable employment and tenants over time.
- Extreme weather: St. Louis is prone to extreme weather, including hot summers and cold winters, as well as tornadoes and severe storms.

It is important to weigh the advantages and disadvantages and determine what is most important for your personal goals and preferences before making a real estate purchase in St. Louis, Missouri.