De Pere is a vibrant and growing city, with a population of around 24,000 and is closely located (only 5 miles) to a major urban center, Green Bay. Here are some general pros and cons to consider when thinking of purchasing real estate in De Pere, Wisconsin:

Pros:
- Affordable housing: In comparison to major urban centers in the US, De Pere has relatively affordable housing options.
- Growing city: De Pere is a growing city with a thriving economy and plenty of job opportunities in areas such as healthcare, manufacturing, and education.
- Education: De Pere has highly rated public schools and several private school options, making the city an attractive option for families.
- Natural Attractions: The city is surrounded by natural attractions such as parks, golf courses, and hiking and biking trails.
- Proximity to Green Bay: Green Bay is a major urban center with excellent shopping, dining, and entertainment options. Being only 5 miles away makes De Pere an attractive choice for those who want a bit of city life but would rather live in a smaller community.

Cons:
- Harsh Winters: As with most places in the Northern US, De Pere has long, cold winters with snow and sub-zero temperatures.
- Limited Public Transportation: De Pere, like many small American cities, do not have extensive public transport, and so owning a car or other vehicle may be necessary.
- Potential Flooding: De Pere experienced some flooding in past years.
- Limited Nightlife: De Pere is a relatively small city with a population of just under 25,000, and so it may not offer the vibrant nightlife of bigger cities like Green Bay or Milwaukee.

Overall, De Pere seems like a lovely city to purchase real estate in, offering affordable housing, natural attractions, and access to a thriving urban center. However, it is important to consider whether you can handle the harsh winters and whether the lack of nightlife or public transportation will fit your lifestyle.